The following emulated build using binfmt should work according to the documentation example at https://guix.gnu.org/manual/en/html_node/Native-Builds.html $ uname -m x86_64 The package was previously built on an aarch64 offload machine: $ file $(guix build --system=aarch64-linux hello)/bin/hello /gnu/store/s2qnbdlrwlx47h5p6rxlylny1259srmj-hello-2.12.1/bin/hello: ELF 64-bit LSB executable, ARM aarch64, version 1 (SYSV), dynamically linked, interpreter /gnu/store/gfjp8gfv4xxschbaxvldpigadfwqazhw-glibc-2.33/lib/ld-linux-aarch64.so.1, for GNU/Linux 2.6.32, stripped Successfully executed using binfmt emulation: $ $(guix build --system=aarch64-linux hello)/bin/hello Hello, world! A locally emulated check build fails during the test phase: $ guix describe Generation 35 Mar 13 2023 13:37:24 (current) guix 1ed227d repository URL: https://git.savannah.gnu.org/git/guix.git branch: master commit: 1ed227d7952af48efe50a2f6c9537e17c356daa1 $ guix build --check --system=aarch64-linux --verbosity=1 hello The following derivation will be built: /gnu/store/sg9mpl4nf7j2w8bmv5q4725gpirhi225-hello-2.12.1.drv building /gnu/store/sg9mpl4nf7j2w8bmv5q4725gpirhi225-hello-2.12.1.drv... | 'check' phasebuilder for `/gnu/store/sg9mpl4nf7j2w8bmv5q4725gpirhi225-hello-2.12.1.drv' failed with exit code 1 build of /gnu/store/sg9mpl4nf7j2w8bmv5q4725gpirhi225-hello-2.12.1.drv failed View build log at '/var/log/guix/drvs/sg/9mpl4nf7j2w8bmv5q4725gpirhi225-hello-2.12.1.drv.gz'. guix build: error: build of `/gnu/store/sg9mpl4nf7j2w8bmv5q4725gpirhi225-hello-2.12.1.drv' failed $ zcat /var/log/guix/drvs/sg/9mpl4nf7j2w8bmv5q4725gpirhi225-hello-2.12.1.drv.gz [...] Test suite failed, dumping logs. --- ./test-suite.log -------------------------------------------------------- ======================================== GNU Hello 2.12.1: ./test-suite.log ======================================== # TOTAL: 7 # PASS: 4 # SKIP: 1 # XFAIL: 0 # FAIL: 2 # XPASS: 0 # ERROR: 0 .. contents:: :depth: 2 FAIL: tests/atexit-1 ==================== FAIL tests/atexit-1 (exit status: 1) SKIP: tests/greeting-2 ====================== ./tests/greeting-2: Skipping test: not a full moon night SKIP tests/greeting-2 (exit status: 77) FAIL: tests/operand-1 ===================== 1,2c1,2 < hello: extra operand: first < Try 'hello --help' for more information. --- > ./hello: extra operand: first > Try './hello --help' for more information. FAIL tests/operand-1 (exit status: 1) error: in phase 'check': uncaught exception: %exception #<&invoke-error program: "make" arguments: ("check" "-j" "2") exit-status: 2 term-signal: #f stop-signal: #f> phase `check' failed after 15.0 seconds command "make" "check" "-j" "2" failed with status 2