Hello, In a shell environment that contains texlive instead of texlive-base, $TEXMF contains the path to texlive packages directly, indead of the path to all packages in the profile. It is a problem for packages obtained from another channel / custom package definitions, which are then not found. > guix shell texlive -- kpsewhich -all -var-value TEXMF > {{}/home/elias/.texlive2021/texmf-config,/home/elias/.texlive2021/texmf-var,/home/elias/texmf,/gnu/store/j63hhbhiycaab3rx4fr0g96vybdfxmax-texlive-20210325/share/texmf-local,!!/gnu/store/7binnxi4w7sxlnpns2qa4yc94bfbfkqf-texlive-texmf-20210325/share/texmf-config,!!/gnu/store/7binnxi4w7sxlnpns2qa4yc94bfbfkqf-texlive-texmf-20210325/share/texmf-var,!!/gnu/store/7binnxi4w7sxlnpns2qa4yc94bfbfkqf-texlive-texmf-20210325/share/texmf-dist} > guix shell texlive-base -- kpsewhich -all -var-value TEXMF > {/gnu/store/jdfsq5k23cz70p68jmiyjca2asg7r1ll-profile/share/texmf-dist} My workaround was to set TEXMFHOME to $GUIX_ENVIRONMENT/share/texmf-dist in my (fish) shell configuration so it is expanded when entering the guix environment, but it doesn't work when running the command directly (as in guix shell texlive -- lualatex file).