Hi, Using Guix ebf07a0. I do not know if the issue is about multi-debs or if I am doing something wrong but IIUC ’apt’ remove all the files under data/. $ /gnu/store/3v93dzrmh978mljw65zvvydm2w8lqaam-guile-wrapper/bin/guile --version guile (GNU Guile) 3.0.7 Copyright (C) 2021 Free Software Foundation, Inc. License LGPLv3+: GNU LGPL 3 or later . This is free software: you are free to change and redistribute it. There is NO WARRANTY, to the extent permitted by law. $ guix gc --references /gnu/store/3v93dzrmh978mljw65zvvydm2w8lqaam-guile-wrapper /gnu/store/01b4w3m6mp55y531kyi1g8shh722kwqm-gcc-7.5.0-lib /gnu/store/226ljnvrhnrb3ngjn0m6i5ih2301bbj0-guile-launcher.c /gnu/store/6l9rix46ydxyldf74dvpgr60rf5ily0c-guile-3.0.7 /gnu/store/fa6wj5bxkj5ll1d7292a70knmyl7a0cr-glibc-2.31 /gnu/store/xa45bzcbib4zqa7gk70nb35dzzwyr376-gcc-toolchain-7.5.0 $ sudo apt install y74azsczq1dws1slmagc1jq6ysidllpb-hello-deb-pack.deb $ guix gc --references $(realpath $(which hello)) /gnu/store/01b4w3m6mp55y531kyi1g8shh722kwqm-gcc-7.5.0-lib /gnu/store/a462kby1q51ndvxdv3b6p0rsixxrgx1h-hello-2.10 /gnu/store/fa6wj5bxkj5ll1d7292a70knmyl7a0cr-glibc-2.31 $ sudo apt remove hello $ ls /gnu/store/01b4w3m6mp55y531kyi1g8shh722kwqm-gcc-7.5.0-lib ls: cannot access '/gnu/store/01b4w3m6mp55y531kyi1g8shh722kwqm-gcc-7.5.0-lib': No such file or directory $ ls -l /gnu/store/3v93dzrmh978mljw65zvvydm2w8lqaam-guile-wrapper/bin/guile -r-xr-xr-x 2 root root 17472 Jan 1 1970 /gnu/store/3v93dzrmh978mljw65zvvydm2w8lqaam-guile-wrapper/bin/guile $ /gnu/store/3v93dzrmh978mljw65zvvydm2w8lqaam-guile-wrapper/bin/guile --version bash: /gnu/store/3v93dzrmh978mljw65zvvydm2w8lqaam-guile-wrapper/bin/guile: No such file or directory $ ar -xv y74azsczq1dws1slmagc1jq6ysidllpb-hello-deb-pack.deb x - debian-binary x - control.tar.xz x - data.tar.xz $ tar Jtf data.tar.xz | grep glibc | head ./gnu/store/01b4w3m6mp55y531kyi1g8shh722kwqm-gcc-7.5.0-lib/lib/gcc/x86_64-unknown-linux-gnu/7.5.0/plugin/include/config/glibc-stdint.h ./gnu/store/fa6wj5bxkj5ll1d7292a70knmyl7a0cr-glibc-2.31/ ./gnu/store/fa6wj5bxkj5ll1d7292a70knmyl7a0cr-glibc-2.31/bin/ ./gnu/store/fa6wj5bxkj5ll1d7292a70knmyl7a0cr-glibc-2.31/bin/catchsegv ./gnu/store/fa6wj5bxkj5ll1d7292a70knmyl7a0cr-glibc-2.31/bin/gencat ./gnu/store/fa6wj5bxkj5ll1d7292a70knmyl7a0cr-glibc-2.31/bin/getconf ./gnu/store/fa6wj5bxkj5ll1d7292a70knmyl7a0cr-glibc-2.31/bin/getent ./gnu/store/fa6wj5bxkj5ll1d7292a70knmyl7a0cr-glibc-2.31/bin/iconv ./gnu/store/fa6wj5bxkj5ll1d7292a70knmyl7a0cr-glibc-2.31/bin/ldd ./gnu/store/fa6wj5bxkj5ll1d7292a70knmyl7a0cr-glibc-2.31/bin/locale Therefore, installing and then removing ’hello’ breaks any other pack using, for instance, 01b4w3m6mp55y531kyi1g8shh722kwqm-gcc-7.5.0-lib or fa6wj5bxkj5ll1d7292a70knmyl7a0cr-glibc-2.31. Do I miss something? Cheers, simon