I just talked with Leo on IRC and he thinks the following might be related. `guix` stopped working, now taking any arguments without effect. I found out that the associated store item is empty! $which guix /home/thorwil/.config/guix/current/bin/guix $ls -l /home/thorwil/.config/guix/current/bin/guix ... /gnu/store/xa1xx4gpnvvf4wpzx63v1swl7gvqyw5d-guix-command $file /gnu/store/xa1xx4gpnvvf4wpzx63v1swl7gvqyw5d-guix-command ... empty This is on just about 1 week old hardware, Ubuntu Unity 20.10, Kernel 5.8.0-38, no power failures, ext4 file system. No direct manipulation, just using `guix pull`, updating, installing and removing packages. Meanwhile, `sudo guix pull` still worked. As suggested by Leo, I did: $cd /var/guix/profiles/per-user/thorwil $rm current-guix $ln -s current-guix-4-link current-guix (Trying to `ln -s current-guix-4-link current-guix` without moving current-guix out of the way first, failed with: "ln: failed to create symbolic link 'current-guix/current-guix-4-link': Read-only file system".) -- Thorsten Wilms