Nicolas Goaziou writes: > You're right. The above fixes the issue with fontconfig. Unfortunately, > the problem persists with the minimal manifest: > > (specifications->manifest '("python-matplotlib")) > > So there's something else going on. > > In order to fix the above, I need to put > > unset GI_TYPELIB_PATH > > in my .profile, after having sourced Guix profile. Maybe this > environment variable also has a special default value when unset. Can you try again with `export GI_TYPELIB_PATH=/usr/lib/girepository-1.0/` before sourcing the profile? Best, Josselin Poiret