Hello, I see people mentioning here that there doesn't seem to be a general solution to be included in Guix for this, but I als do not understand what the particular solution (for my machine, for example) is supposed to be. I'm a new user to Guix and also not technically very experienced with Linux OS's, so feel free to point me out something obvious I have missed. I currently have Guix on top of Ubuntu 20.04, and I have this exact problem with XDG_DATA_DIRS being exported on startup of Gnome and breaking it, and i happend when this variable is added to ~/.guix-profile/etc/profile when installing certain packages; the ones detected so far where python-ipython, python-ipykernel and python-notebook. As far as I unedrstand, when Ubuntu starts up, it runs /etc/profile, which in turn reads through all scripts inside /etc/profile.d. In that dir, we have guix.sh, which I will paste here: # _GUIX_PROFILE: `guix pull` profile _GUIX_PROFILE="$HOME/.config/guix/current" export PATH="$_GUIX_PROFILE/bin${PATH:+:}$PATH" # Export INFOPATH so that the updated info pages can be found # and read by both /usr/bin/info and/or $GUIX_PROFILE/bin/info # When INFOPATH is unset, add a trailing colon so that Emacs # searches 'Info-default-directory-list'. export INFOPATH="$_GUIX_PROFILE/share/info:$INFOPATH" # GUIX_PROFILE: User's default profile GUIX_PROFILE="$HOME/.guix-profile" [ -L $GUIX_PROFILE ] || return GUIX_LOCPATH="$GUIX_PROFILE/lib/locale" export GUIX_PROFILE GUIX_LOCPATH [ -f "$GUIX_PROFILE/etc/profile" ] && . "$GUIX_PROFILE/etc/profile" # set XDG_DATA_DIRS to include Guix installations export XDG_DATA_DIRS="$GUIX_PROFILE/share:${XDG_DATA_DIRS:-/usr/local/share/:/usr/share/}" The culprit in this case seems to be [ -f "$GUIX_PROFILE/etc/profile" ] && . "$GUIX_PROFILE/etc/profile", and this is because it is getting the following two lines from $GUIX_PROFILE/etc/profile which are introduced by installing python-ipython (for example): export GI_TYPELIB_PATH="${GUIX_PROFILE:-/gnu/store/22lc31mr4h00x5swzk73293pm2xpaahi-profile}/lib/girepository-1.0${GI_TYPELIB_PATH:+:}$GI_TYPELIB_PATH" export XDG_DATA_DIRS="${GUIX_PROFILE:-/gnu/store/22lc31mr4h00x5swzk73293pm2xpaahi-profile}/share${XDG_DATA_DIRS:+:}$XDG_DATA_DIRS" In fact, when this happens, the last line in guix.sh is only duplicating what the line inside .guix-profile/etc/profile had already exported: export XDG_DATA_DIRS="$GUIX_PROFILE/share:${XDG_DATA_DIRS:-/usr/local/share/:/usr/share/}" What is the workaround that can be used here? I only see two possible solutions, which are unsatisfactory to me: * Refrain from installing packages that alter this variable; * Comment all lines inside guix.sh and add . "$GUIX_PROFILE/etc/profile to my .bash_rc file, focing me to open a terminal everytime I want to launch guix installed packages.Is there another alternative for this? Eagerly awating for feedback on this, as it's completely destroying my workflow; I am never sure when  will install a package that wll break Ubuntu. Thanks, Tomás